By Eric Beitz
The aquaporin box has matured at an extremely quick speed and we're on the verge to improve severe concepts to therapeutically modulate aquaporin functionality without delay or through regulatory networks. Key necessities can be found this present day: i. a substantial (and turning out to be) variety of aquaporin crystal constructions for the rational layout of inhibitory molecules, ii. complicated molecular dynamics simulation concepts for theoretical analyses of selectivity mechanisms and docking experiments, iii. accomplished facts on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological reports, and v. assay platforms for compound library screenings. The constitution of this quantity on aquaporins follows the issues laid out above and therefore covers the advancements from uncomplicated study to strength pharmacological use. positioned among pharmacology textbooks and up to date medical papers this booklet presents a well timed assessment for readers from the basic in addition to the utilized disciplines.
Read or Download Aquaporins: 190 (Handbook of Experimental Pharmacology) PDF
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